Chapter

Biological principles of hormone therapy

Danish Mazhar and Jonathan Waxman

in Systemic Treatment of Prostate Cancer

Published on behalf of Oxford University Press

ISBN: 9780199561421
Published online May 2011 | e-ISBN: 9780199607372 | DOI: http://dx.doi.org/10.1093/med/9780199561421.003.0001

Series: Oxford Oncology Library

Biological principles of hormone therapy

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• Androgen receptor (AR) signalling is necessary for the development of prostate cancer • Androgens exert their biological effects through AR • Androgen-deprivation therapy for prostate cancer was described over 50 years ago and remains the mainstay of systemic therapy • Although the mechanisms by which prostate cancer cells change androgen sensitivity are unclear, it is believed that the tumour cells must either bypass or adapt the AR-mediated cell growth pathway in order to survive in a low androgen microenvironment during androgen ablation therapy • With increasing understanding of the genes and pathways that drive castration-refratory prostate cancer, therapeutic agents are being developed that act on the key molecular targets.

Chapter.  1952 words. 

Subjects: Clinical Oncology

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