Systemic isotope therapy of bone metastasis

Christopher C Parker

in Systemic Treatment of Prostate Cancer

Published on behalf of Oxford University Press

Published in print February 2010 | ISBN: 9780199561421
Published online May 2011 | e-ISBN: 9780191740251 | DOI:

Series: Oxford Oncology Library

Systemic isotope therapy of bone metastasis

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Sr-89 or Sm-153 improve pain control and quality of life, and delay the onset of new bone pain in men with CRPC and bone metastases

Sr-89 or Sm-153 are recommended as standard of care in current prostate cancer treatment guidelines

Sr-89 or Sm-153 may have a useful role not just in pain relief, but also in the prevention of skeletal-related events

Sr-89 and Sm-153 can cause haematologic toxicity, and should not normally be used in men who are likely to require cytotoxic chemotherapy

Ra-223 is a bone seeking alpha emitter, which may offer a better therapeutic ratio, with less myelosuppression.

Chapter.  2481 words.  Illustrated.

Subjects: Radiation Oncology

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