Chapter

Aetiology and molecular basis of disease

Maxine Tran and Tim Eisen

in Renal Cancer

Published on behalf of Oxford University Press

ISBN: 9780199562312
Published online September 2011 | e-ISBN: 9780199607402 | DOI: http://dx.doi.org/10.1093/med/9780199562312.003.0001

Series: Oxford Oncology Library

Aetiology and molecular basis of disease

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• Renal cancer is the commonest malignancy of the kidney • Clear cell renal cancer is the commonest form of renal cancer • Smoking accounts for 25% of the disease • Different genetic abnormalities and molecular mechanisms underpin the different histological subtypes • Defective function of the VHL gene underlies 80% of clear cell renal cancers.

Chapter.  2358 words. 

Subjects: Clinical Oncology

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