Systemic treatment: targeted therapies

Tanya Dorff and David Quinn

in Renal Cancer

Published on behalf of Oxford University Press

ISBN: 9780199562312
Published online September 2011 | e-ISBN: 9780199607402 | DOI:

Series: Oxford Oncology Library

Systemic treatment: targeted therapies

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• The vascular endothelial growth factor (VEGF) pathway is critical for renal cell carcinoma (RCC) survival and metastasis • Multitargeted tyrosine kinase inhibitors (TKIs) which inhibit the VEGF pathway prolong time to disease progression and overall survival in advanced RCC • The mammalian target of rapamycin (mTOR) is aberrant in a significant number of renal cancers and is a second critical pathway in RCC • mTOR inhibitors prolong time to disease progression and overall survival in select groups of patients with RCC • Toxicities of VEGF tyrosine kinase and mTOR inhibitors used for RCC therapy require close monitoring, management, and at times dosage modifications.

Chapter.  3369 words.  Illustrated.

Subjects: Radiation Oncology

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