Edited by Michael I. Bennett

in Neuropathic Pain

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199563678
Published online May 2011 | e-ISBN: 9780199607426 | DOI:

Series: Oxford Pain Management Library


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• Opioid receptor structure and function can be altered in neuropathic pain states, leading to reduced sensitivity to opioids • Opioids were thought to be ineffective for neuropathic pain but substantial evidence exists to demonstrate analgesic efficacy, in some cases superior to more commonly used co-analgesics • The most convincing evidence supports use of morphine, oxycodone, and tramadol in neuropathic pain • Methadone, buprenorphine, and fentanyl may have a role but are supported by less convincing evidence, though the evidence base is growing rapidly • Opioids should be used with caution in chronic pain management because of unknown long-term effects and risk of misuse. Adherence to local protocols and guidelines is recommended.

Chapter.  3875 words. 

Subjects: Anaesthetics ; Pain Medicine

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