Chapter

T cells and B cells in lupus nephritis

Mary H. Foster

in Lupus Nephritis

Second edition

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780199568055
Published online November 2012 | e-ISBN: 9780191753374 | DOI: http://dx.doi.org/10.1093/med/9780199568055.003.0003

Series: Oxford Clinical Nephrology Series

T cells and B cells in lupus nephritis

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The immune system plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) and lupus nephritis, the most common serious complication. Disease manifestations result from effector pathways set in motion by activated and tissue-infiltrating lymphocytes and mononuclear cells, secreted cytokines, and circulating and deposited autoantibodies. These effectors are, in turn, the product of an autoimmune response unleashed from normal controls by the interaction of complex genetic and environmental factors. T and B lymphocytes lie at the heart of autoimmunity, defining antigen specificity and modulating each step in pathogenesis: initiation, regulation, amplification, tissue infiltration, organ destruction, and disease resolution. This chapter will review the role of adaptive immunity and its dysregulation in lupus nephritis, with emphasis on recent insights and promising new targets for immune intervention.

Chapter.  11003 words.  Illustrated.

Subjects: Nephrology

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