Chapter

The many effects of complement in lupus nephritis

Lihua Bao* and Richard J. Quigg

in Lupus Nephritis

Second edition

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780199568055
Published online November 2012 | e-ISBN: 9780191753374 | DOI: http://dx.doi.org/10.1093/med/9780199568055.003.0004

Series: Oxford Clinical Nephrology Series

The many effects of complement in lupus nephritis

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The involvement of the complement system in the pathogenesis of a number of autoimmune diseases is well accepted, yet its exact roles are still unclear. On one hand, hereditary deficiencies of early classical pathway complement components predispose patients to SLE. On the other hand, activation of complement by ICs is certainly a prominent feature in SLE. Therefore, an imbalance of the complement system in either way can be relevant to the development of this disease. In this chapter, we will discuss the dual roles of complement in SLE, and in particular in lupus nephritis. The relevance of what we now know of this system to potential treatment of human SLE will be emphasized.

Chapter.  11350 words.  Illustrated.

Subjects: Nephrology

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