Chapter

Pathways of cellular adaptive immunity in autoimmune crescentic glomerulonephritis and lupus nephritis

Stephen R. Holdsworth and Peter G. Tipping

in Lupus Nephritis

Second edition

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780199568055
Published online November 2012 | e-ISBN: 9780191753374 | DOI: http://dx.doi.org/10.1093/med/9780199568055.003.0005

Series: Oxford Clinical Nephrology Series

Pathways of cellular adaptive immunity in autoimmune crescentic glomerulonephritis and lupus nephritis

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T cell-directed adaptive immunity underpins many forms of GN and particularly crescentic GN. T cell-driven autoimmunity and Th1 cell-driven effector mechanisms play an important role in crescentic human GN. The involvement of Th17 cells and regulatory T cells is currently poorly understood. There is an increasing awareness of the important role of dendritic cells, TLRs, and type I interferons in autoimmunity and lupus, which is revealing potential new therapeutic targets that may result in new therapies for autoimmune crescentic GN.

Chapter.  12106 words.  Illustrated.

Subjects: Nephrology

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