Chapter

Renal vascular involvement in SLE

Ben Sprangers and Gerald B. Appel

in Lupus Nephritis

Second edition

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780199568055
Published online November 2012 | e-ISBN: 9780191753374 | DOI: http://dx.doi.org/10.1093/med/9780199568055.003.0009

Series: Oxford Clinical Nephrology Series

Renal vascular involvement in SLE

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Renal vascular lesions in patients with SLE range from those of minor clinical relevance to those associated with marked renal impairment and a major increase in morbidity in patients. They may complicate any pattern of glomerular lesion ranging from mesangial involvement to severe proliferative disease. The thrombotic microangiopathies may cause major glomerular and large vessel involvement in SLE patients, and require intervention with anticoagulation and other modalities not usually included in the immunosuppressive treatment of these patients. Although overlooked in many recent histological studies of chronicity and activity on lupus renal biopsies, there is little doubt that vascular lesions can greatly influence the course and treatment of patients with SLE.

Chapter.  11186 words.  Illustrated.

Subjects: Nephrology

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