Chapter

Optimal medical therapy in percutaneous coronary intervention patients: statins and ACE inhibitors as disease-modifying agents

Simon J. Corbett and Kim F. Fox

Edited by Nick Curzen

in Oxford Textbook of Interventional Cardiology

Published on behalf of Oxford University Press

ISBN: 9780199569083
Published online July 2011 | e-ISBN: 9780199697816 | DOI: http://dx.doi.org/10.1093/med/9780199569083.003.026

Series: Oxford Textbooks

Optimal medical therapy in percutaneous coronary intervention patients: statins and ACE inhibitors as disease-modifying agents

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The majority of this textbook is concerned with the indications for, and applications of, the numerous techniques that interventional cardiologists have at their disposal to assess and treat significant coronary stenoses. However, it is well recognized that atherosclerosis is far from being a discrete pathological process, such that by the time a person presents with clinically apparent coronary artery disease (CAD), they will often have widespread atheroma throughout their coronary tree. Combined with the reproducible observation that the majority of acute coronary syndromes arise from lesions that were not previously flow-limiting, much research effort has been directed at identifying treatment strategies that will favourably modify all of the patient’s atherosclerotic burden, not just that which can be targeted by percutaneous or surgical revascularization. In this chapter, we focus on the rationale and evidence base supporting the use of statins and renin–angiotensin–aldosterone system (RAAS) inhibition in patients with CAD.

Chapter.  13150 words.  Illustrated.

Subjects: Radiology ; Cardiovascular Medicine

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