Chapter

Mechanisms of atherogenesis

Paul Nicholls and Ian Young

in Lipid Disorders

Published on behalf of Oxford University Press

ISBN: 9780199569656
Published online May 2011 | e-ISBN: 9780199607464 | DOI: http://dx.doi.org/10.1093/med/9780199569656.003.0005

Series: Oxford Cardiology Library

Mechanisms of atherogenesis

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• Atherosclerosis is caused by lipid deposition and inflammation in the arterial wall. • Native low-density lipoprotein (LDL) is atherogenic when modified, for example by oxidation. • Unstable plaques may rupture and cause acute thrombotic occlusion. • Lipid-lowering treatment can reduce plaque size and increase stability.

Chapter.  1649 words.  Illustrated.

Subjects: Cardiovascular Medicine

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