Chapter

Neurobiology of depression

Roger S. McIntyre and Jay Nathanson

in Severe Depression

Published on behalf of Oxford University Press

ISBN: 9780199570249
Published online May 2011 | e-ISBN: 9780199607471 | DOI: http://dx.doi.org/10.1093/med/9780199570249.003.0006

Series: Oxford Psychiatry Library

Neurobiology of depression

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• There are three major networks associated with the pathophysiology (and possibly treatment) of MDD: the immunoinflammatory network, the metabolic network (e.g., insulin, insulin-growth factor), and the neuroendocrine network (e.g., cortisol) • Disturbances in neuroplasticity and neurotrophism are implicated as critical pathophysiological processes in MDD manifested as alterations in neurotransmitter signalling and changes in cellular resilience and survival • Exposure to environmental pathogens (e.g., proximal and psychosocial stressors) accounts for a significant proportion of the population attributable risk for MDD • Unraveling gene-environment interactions are a critical research vista for the future

Chapter.  5706 words.  Illustrated.

Subjects: Psychiatry

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