Respiratory causes of pulmonary hypertension

Tamera Jo Corte and S John Wort

in Pulmonary Arterial Hypertension

Published on behalf of Oxford University Press

ISBN: 9780199572632
Published online January 2012 | e-ISBN: 9780199607495 | DOI:

Series: Oxford Cardiology Library

Respiratory causes of pulmonary hypertension

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• Pulmonary hypertension (PH) associated with lung disease or hypoxaemia is a distinct subgroup of PH • PH related to respiratory disease is often mild- to-moderate in severity. However, PH may be out-of-proportion and moderate to severe to the underlying lung disease in a minority of patients. The presence of PH is associated with poorer survival • Multiple mechanisms often contribute to the pathophysiology of PH related to lung disease including: chronic hypoxaemia, destruction of the pulmonary vasculature, true vascular remodelling, in situ thrombosis, and upset of the pulmonary angiogenesis/angiostasis balance • Management is based upon treatment of the under lying disorder(s), their complications, and reversal of resting hypoxaemia. There have been no successful randomized-controlled trials for specific PH therapies in respiratory patients, so no routine specific PH therapy is recommended. However, uncontrolled trials and case-series for endothelin-receptor antagonists and vasodilators have been encouraging. Larger placebo-controlled trials are underway.

Chapter.  4262 words.  Illustrated.

Subjects: Cardiovascular Medicine

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