Chapter

Respiratory causes of pulmonary hypertension

Tamera Jo Corte and S John Wort

in Pulmonary Arterial Hypertension

Published on behalf of Oxford University Press

ISBN: 9780199572632
Published online January 2012 | e-ISBN: 9780199607495 | DOI: http://dx.doi.org/10.1093/med/9780199572632.003.0010

Series: Oxford Cardiology Library

Respiratory causes of pulmonary hypertension

Show Summary Details

Preview

• Pulmonary hypertension (PH) associated with lung disease or hypoxaemia is a distinct subgroup of PH • PH related to respiratory disease is often mild- to-moderate in severity. However, PH may be out-of-proportion and moderate to severe to the underlying lung disease in a minority of patients. The presence of PH is associated with poorer survival • Multiple mechanisms often contribute to the pathophysiology of PH related to lung disease including: chronic hypoxaemia, destruction of the pulmonary vasculature, true vascular remodelling, in situ thrombosis, and upset of the pulmonary angiogenesis/angiostasis balance • Management is based upon treatment of the under lying disorder(s), their complications, and reversal of resting hypoxaemia. There have been no successful randomized-controlled trials for specific PH therapies in respiratory patients, so no routine specific PH therapy is recommended. However, uncontrolled trials and case-series for endothelin-receptor antagonists and vasodilators have been encouraging. Larger placebo-controlled trials are underway.

Chapter.  4262 words.  Illustrated.

Subjects: Cardiovascular Medicine

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.