Chapter

Pathogenesis

Edmund Sonuga-Barke

in Attention-Deficit Hyperactivity Disorder and Hyperkinetic Disorder

Published on behalf of Oxford University Press

ISBN: 9780199577651
Published online May 2011 | e-ISBN: 9780199607525 | DOI: http://dx.doi.org/10.1093/med/9780199577651.003.0003

Series: Oxford Psychiatry Library

Pathogenesis

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ADHD appears to have a complex etiology. There are multiple genetic and environmental risk factors of small effect that act in concert to create a spectrum of neurobiological liability. Understanding the etiology of ADHD will depend crucially on modelling the interplay between genetic and environmental risk factors in terms of both gene-environment correlations and interactions. Cognitive impairment in ADHD is not fixed but appears to be highly context dependent suggesting that an individuals state and levels of motivation in relation to a task or setting are important in determining performance. ADHD is not a single pathophysiological entity and there may be different subgroups of individual patients with different profiles of neuropsychological impairment.

Chapter.  4866 words.  Illustrated.

Subjects: Child and Adolescent Psychiatry

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