Benjamin R. Szwejkowski, Sushma Rekhraj and Allan Struthers

in Oxford Textbook of Heart Failure

Published on behalf of Oxford University Press

ISBN: 9780199577729
Published online July 2011 | e-ISBN: 9780199697809 | DOI:

Series: Oxford Textbooks


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Arginine vasopressin (AVP; also known as antidiuretic hormone, ADH) is a polypeptide hormone synthesized by the neurosecretory cells of the supraoptic nucleus located within the hypothalamus.Vasopressin is packaged into secretory vesicles and transported by fast axons through the pituitary stalk to the posterior pituitary gland. The posterior pituitary gland acts as a supporting structure for the axonal nerve endings which lie on the surfaces of capillaries and it is here that vasopressin is secreted directly into the bloodstream. Oxytocin is also released by nerves in the posterior pituitary gland, but synthesized within a different nucleus of the hypothalamus called the paraventricular nucleus. Vasopressin contains nine amino acids and is similar in structure to oxytocin except that in vasopressin the isoleucine and leucine of oxytocin are replaced by phenylalanine and arginine.

Chapter.  3190 words.  Illustrated.

Subjects: Cardiovascular Medicine

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