Diastolic heart failure

Andrew L. Clark

in Oxford Textbook of Heart Failure

Published on behalf of Oxford University Press

ISBN: 9780199577729
Published online July 2011 | e-ISBN: 9780199697809 | DOI:

Series: Oxford Textbooks

Diastolic heart failure

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The vast majority of clinical trials in patients with chronic heartfailure (CHF) have been conducted in patients with left ventricularsystolic dysfunction (LVSD). Although defining CHF can be difficult, its pragmatic definition requiring symptoms compatible withthe syndrome in the presence of cardiac dysfunction makes LVSDrelatively easy to identify. This is the appeal of the left ventricularejection fraction (LVEF) as a measurement — a normal range canbe established, and those people who are breathless on exertionand whose ejection fraction falls below the normal range arelabelled as having heart failure (HF).This pragmatic approach to identifying patients who should betreated leaves a large group of people who have undoubted symptomscompatible with a diagnosis of CHF, but who have normal(or at most mildly impaired) left ventricular systolic function.There are many reports suggesting that perhaps half of all patientswith HF fall into this category, and various labels are used.

Chapter.  5912 words.  Illustrated.

Subjects: Cardiovascular Medicine

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