Chronic lung disease

Michael Greenstone, Simon P. Hart and Nathaniel M. Hawkins

in Oxford Textbook of Heart Failure

Published on behalf of Oxford University Press

ISBN: 9780199577729
Published online July 2011 | e-ISBN: 9780199697809 | DOI:

Series: Oxford Textbooks

Chronic lung disease

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Chronic obstructive pulmonary disease (COPD) and heart failure(HF) commonly occur in the same patient and the presence of onewill affect the prognosis from the other. There is a growing body ofevidence linking COPD and vascular events. When the NationalHealth and Nutrition Examination Survey population was stratified by forced expiratory volume in 1 s (FEV1) and examined forcause of death, then the risk of death from cardiovascular disease was as much as fivefold greater in those with the lowest FEV1 compared to the highest. Studies in Malmo and Baltimore showed thatthose with the most rapidly declining FEV1 were most likely to dieof cardiovascular disease. Low baseline FEV1 also predicts strokemortality, all-cause cancer mortality, and death from nonrespiratory, noncardiac causes. Thus cardiac disease and respiratoryfunction are strongly correlated: although smoking is the obviouscommon risk factor, the relationship still stands in nonsmokers. Itis possible that FEV1 is a marker for an ill-defined environmentalfactor such as poor nutrition but it could also be a marker of asystemic process of chronic tissue damage and abnormal repair.

Chapter.  6551 words.  Illustrated.

Subjects: Cardiovascular Medicine

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