Chapter

Systemic lupus erythematosus (SLE) in pregnancy

Aisha Lateef and M. Petri

in Rheumatology and the Kidney

Second edition

Published on behalf of Oxford University Press

Published in print April 2012 | ISBN: 9780199579655
Published online February 2013 | e-ISBN: 9780191763472 | DOI: http://dx.doi.org/10.1093/med/9780199579655.003.0038

Series: Oxford Clinical Nephrology Series

Systemic lupus erythematosus (SLE) in pregnancy

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1. Pregnancy in SLE is associated with increased maternal and foetal morbidity including disease flares, foetal loss, prematurity, IUGR and pre-eclampsia. 2. Disease flares are more common during pregnancy. 3. Disease activity at the time of conception is associated with poor outcomes. 4. Pre-conception assessment is necessary to risk-stratify the patients. 5. Differentiation between renal flares and pre-eclampsia may be difficult in some cases. 6. Pre-term births are frequent in SLE pregnancies. The combination of highly active clinical lupus and abnormal serological tests (low complement, high anti-dsDNA) is most predictive of pre-term birth. 7. Pharmacotherapy during pregnancy needs to be adjusted for the safety of the mother and foetus.

Chapter.  6065 words. 

Subjects: Nephrology

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