Systemic lupus erythematosus (SLE) in pregnancy

Aisha Lateef and M. Petri

in Rheumatology and the Kidney

Second edition

Published on behalf of Oxford University Press

Published in print April 2012 | ISBN: 9780199579655
Published online February 2013 | e-ISBN: 9780191763472 | DOI:

Series: Oxford Clinical Nephrology Series

Systemic lupus erythematosus (SLE) in pregnancy

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1. Pregnancy in SLE is associated with increased maternal and foetal morbidity including disease flares, foetal loss, prematurity, IUGR and pre-eclampsia. 2. Disease flares are more common during pregnancy. 3. Disease activity at the time of conception is associated with poor outcomes. 4. Pre-conception assessment is necessary to risk-stratify the patients. 5. Differentiation between renal flares and pre-eclampsia may be difficult in some cases. 6. Pre-term births are frequent in SLE pregnancies. The combination of highly active clinical lupus and abnormal serological tests (low complement, high anti-dsDNA) is most predictive of pre-term birth. 7. Pharmacotherapy during pregnancy needs to be adjusted for the safety of the mother and foetus.

Chapter.  6065 words. 

Subjects: Nephrology

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