Chapter

Pathology of vasculitis: Wegener's granulomatosis, microscopic polyangiitis, renal limited vasculitis, and Churg–Strauss syndrome

Franco Ferrario and Maria Pia Rastaldi

in Rheumatology and the Kidney

Second edition

Published on behalf of Oxford University Press

Published in print April 2012 | ISBN: 9780199579655
Published online February 2013 | e-ISBN: 9780191763472 | DOI: http://dx.doi.org/10.1093/med/9780199579655.003.0057

Series: Oxford Clinical Nephrology Series

Pathology of vasculitis: Wegener's granulomatosis, microscopic polyangiitis, renal limited vasculitis, and Churg–Strauss syndrome

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1. ANCA-associated renal vasculitis, namely Wegener's granulomatosis, MPA, renal limited vasculitis and Churg–Strauss syndrome, display the same pathological features at renal biopsy. Only true interstitial granulomas are diagnostic of Wegener's granulomatosis. 2. Renal biopsy is a fundamental tool for diagnosis and management. 3. Glomerular and interstitial granulomas are acute lesions, very different from other kinds of chronic granulomatous reactions. 4. Despite the pauci-immune nature of the disease, a role for complement is emerging from more recent experimental and human studies. 5. Treatment options have largely improved prognosis, but relapses and adverse effects remain frequent and better therapies are still required.

Chapter.  2869 words.  Illustrated.

Subjects: Nephrology

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