Chapter

Hepatitis B-associated renal diseases

Kar Neng Lai and Sydney C.W. Tang

in Rheumatology and the Kidney

Second edition

Published on behalf of Oxford University Press

Published in print April 2012 | ISBN: 9780199579655
Published online February 2013 | e-ISBN: 9780191763472 | DOI: http://dx.doi.org/10.1093/med/9780199579655.003.0123

Series: Oxford Clinical Nephrology Series

Hepatitis B-associated renal diseases

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1. HBV-related glomerulopathy is associated with chronic immune complex formation in situ. 2. The pathologies include MN, mesangiocapillary nephropathy and mesangial proliferative GN with IgA deposits. 3. The development of individual pathology is related to the size of the HBV antigens. 4. The glomerulopathy progresses slowly with development of end-stage renal failure if untreated. 5. Anti-viral agents are effective in slowing the progression of the renal failure. Symptomatic improvement occurs with eradication of the virus 6. Prevention by an effective vaccination programme is far superior to anti-viral treatment despite the fact that new anti-viral therapy is promising on a long-term carrier. 7. A national vaccination for newborn in endemic areas is strongly recommended.

Chapter.  5873 words. 

Subjects: Nephrology

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