Chapter

Renal complications of hematopoietic stem cell transplantation

Benjamin D. Humphreys

in Cancer and the Kidney

Second edition

Published on behalf of Oxford University Press

Published in print November 2010 | ISBN: 9780199580194
Published online November 2012 | e-ISBN: 9780191753404 | DOI: http://dx.doi.org/10.1093/med/9780199580194.003.0008

Series: Oxford Clinical Nephrology Series

Renal complications of hematopoietic stem cell transplantation

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Hematopoietic stem cell transplantation (HSCT) offers a cure for both malignant and non-malignant hematologic disease. Despite advances in the procedure leading to rapid growth in number of HSCTs performed over the last two decades, renal complications remain a very important cause of morbidity and mortality. Peri-transplant acute kidney injury (AKI) is common and severe cases are associated with very high mortality. The risk of AKI depends on the type of conditioning (myeloablative or non-myeloablative) and the source of stem cells (autologous or allogeneic). Glomerular disease in HSCT recipients is more common than in the general population, and is associated with graft vs. host disease (GVHD). With increasing numbers of HSCT survivors many years out from transplant, long-term morbidity such as chronic kidney disease (CKD) and end-stage renal disease (ESRD) represent a growing problem.

Chapter.  5787 words.  Illustrated.

Subjects: Nephrology

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