Molecular biology of lung cancer for the clinician

Adi F. Gazdar, Jill E. Larsen and John D. Minna

in Systemic Treatment of Non-Small Cell Lung Cancer

Published on behalf of Oxford University Press

ISBN: 9780199580484
Published online March 2012 | e-ISBN: 9780199607532 | DOI:

Series: Oxford Oncology Library

Molecular biology of lung cancer for the clinician

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• The molecular biology of lung cancer is highly complex with numerous genetic, epigenetic, and cytological changes present in all lung cancers • Considerable progress has been made in identifying the key ‘driver’ mutations essential for the appearance or maintenance of the cancer phenotype • The molecular changes characterizing the major forms of lung cancer, small-cell, adenocarcinoma, and squamous cell carcinomas are distinct • Lung cancer arising in lifetime non smokers (mainly adenocarcinomas) constitute a distinct entity • Advances in medicine and the selection of cases for individualized medicine require greater accuracy in histological classification of non-small-cell lung cancers • Global approaches to studying the complex lung cancer genome landscape have identified many actual or potential targets for therapy • Translation of our considerable laboratory knowledge of lung cancer biology to the clinic will enable us to achieve the goal of personalized medicine for all or most lung cancer patients in the not too distant future.

Chapter.  4687 words. 

Subjects: Medical Oncology

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