Chapter

Combined modality therapy for locally advanced NSCLC

Margaret Edwards and Hak Choy

in Systemic Treatment of Non-Small Cell Lung Cancer

Published on behalf of Oxford University Press

ISBN: 9780199580484
Published online March 2012 | e-ISBN: 9780199607532 | DOI: http://dx.doi.org/10.1093/med/9780199580484.003.0004

Series: Oxford Oncology Library

Combined modality therapy for locally advanced NSCLC

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• Multiple clinical trials have shown improved survival when combining chemotherapy with thoracic radiation therapy for definitive treatment of locally advanced NSCLC • Up-front concurrent chemoradiation therapy provides the best treatment outcomes when compared with sequential therapy or induction chemotherapy, although the efficacy of concurrent chemoradiation must be balanced with its increased toxicity • The benefit of ‘consolidation’ chemotherapy is not supported by phase III clinical trials when full dose chemotherapy is given during the concurrent phase • While a ‘platinum doublet’ is the most commonly used chemotherapy regimen with concurrent thoracic radiation therapy, the optimal chemotherapy agents remain controversial • Targeted biologic agents have shown promise in treatment and will likely have an increasing future role • New technological developments in radiation therapy, such as image-guidance, allow more precise targeting of tumour with increasing radiotherapy dose and normal tissue sparing, thus increasing the rate of local control.

Chapter.  2898 words. 

Subjects: Medical Oncology

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