Chapter

Antibiotics—mechanisms of action

Sebastian G. B. Amyes

in Antibacterial Chemotherapy

Published on behalf of Oxford University Press

ISBN: 9780199581368
Published online May 2011 | e-ISBN: 9780199607549 | DOI: http://dx.doi.org/10.1093/med/9780199581368.003.0002

Series: Oxford Infectious Diseases Library

Antibiotics—mechanisms of action

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• The action of the penicillins and cephalosporins along with vancomycin—inhibitors of bacterial cell wall synthesis. • The selective action of trimethoprim and inhibitors of bacterial folic acid synthesis. • Bacterial protein synthesis, an early target for antibiotics but often now less popular particularly as they generally do not kill bacteria. • The action of ciprofloxacin and metronidazole, still two important inhibitors of bacterial DNA synthesis. • The recent revival of colistin has reawakened interest in antibiotics that affect cell permeability.

Chapter.  3899 words.  Illustrated.

Subjects: Medical Oncology

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