Chapter

Microbiology of CF lung disease

Gerd Döring and Dieter Worlitzsch

in Cystic Fibrosis

Published on behalf of Oxford University Press

ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780199607563 | DOI: http://dx.doi.org/10.1093/med/9780199582709.003.0003

Series: Oxford Respiratory Medicine Library

Microbiology of CF lung disease

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• Bacterial lung infections are the predominant cause of restricted life expectancy of CF patients • Eradication of bacteria chronically infecting the CF lungs is virtually impossible • Bacteria adapt their genotype and phenotype to the specific lung environment • CF lung infection involves a mixed growth of facultative and obligate anaerobes • Anaerobic growth conditions induce Pseudomonas biofilm formation, reduce the efficacy of the human defence system, and impair the effectiveness of antibiotics • Early therapy at the onset of infection offers the best chance of eradication • Many organisms are either innately resistant to multiple antibiotics or are able to acquire resistance.

Chapter.  4436 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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