Chapter

Cystic fibrosis related diabetes

Stephen M. P. O'Riordan and Antoinette Moran

in Cystic Fibrosis

Published on behalf of Oxford University Press

Published in print September 2010 | ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780191740442 | DOI: https://dx.doi.org/10.1093/med/9780199582709.003.0007

Series: Oxford Respiratory Medicine Library

Cystic fibrosis related diabetes

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Diabetes is the most common co-morbidity in CF, with a prevalence of about 50% by 30 years of age

CF related diabetes (CFRD) is generally insidious in onset, and screening with annual oral glucose tolerance testing (OGTT) is recommended

Continuous glucose monitoring can detect abnormalities earlier than OGTT, but the clinical significance of these early changes is unknown

CFRD is predominantly an insulin deficiency state, leading to protein catabolism, weight loss, pulmonary function decline, and early death from lung disease

CFRD is associated with increased morbidity, some studies report a six-fold increase in mortality once CFRD is diagnosed. Clinical decline can be seen 2–6 years prior to diagnosis of diabetes

Early intervention with insulin has been shown to reverse clinical deterioration, even in those with mild diabetes (i.e. without fasting hyperglycaemia).

Chapter.  3738 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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