Cystic fibrosis related diabetes

Stephen M. P. O'Riordan and Antoinette Moran

in Cystic Fibrosis

Published on behalf of Oxford University Press

ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780199607563 | DOI:

Series: Oxford Respiratory Medicine Library

Cystic fibrosis related diabetes

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• Diabetes is the most common co-morbidity in CF, with a prevalence of about 50% by 30 years of age • CF related diabetes (CFRD) is generally insidious in onset, and screening with annual oral glucose tolerance testing (OGTT) is recommended • Continuous glucose monitoring can detect abnormalities earlier than OGTT, but the clinical significance of these early changes is unknown • CFRD is predominantly an insulin deficiency state, leading to protein catabolism, weight loss, pulmonary function decline, and early death from lung disease • CFRD is associated with increased morbidity, some studies report a six-fold increase in mortality once CFRD is diagnosed. Clinical decline can be seen 2–6 years prior to diagnosis of diabetes • Early intervention with insulin has been shown to reverse clinical deterioration, even in those with mild diabetes (i.e. without fasting hyperglycaemia).

Chapter.  3767 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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