Chapter

Metabolic and musculoskeletal effects of CF

Charles Haworth

in Cystic Fibrosis

Published on behalf of Oxford University Press

ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780199607563 | DOI: http://dx.doi.org/10.1093/med/9780199582709.003.0008

Series: Oxford Respiratory Medicine Library

Metabolic and musculoskeletal effects of CF

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• 10–25% of adults with CF have low bone mineral density (BMD) • Risk factors for low BMD include CFTR genotype, male gender, low body mass index (BMI), pulmonary infection/systemic inflammation, pubertal delay, hypogonadism, oral corticosteroid use, vitamin D insufficiency and vitamin K insufficiency • Approximately 10% of adults with CF develop a non-erosive episodic arthritis characterized by painful swelling of the hands, wrists, knees and ankles • Impaired growth in CF is associated with nutritional deficiency, lung infection and systemic inflammation.

Chapter.  3064 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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