Chapter

Lung transplantation

Laura Tanner and Andrew J. Fisher

in Cystic Fibrosis

Published on behalf of Oxford University Press

ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780199607563 | DOI: http://dx.doi.org/10.1093/med/9780199582709.003.0010

Series: Oxford Respiratory Medicine Library

Lung transplantation

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• Lung transplantation should be considered a treatment option for severe CF lung disease uncontrolled on maximal medical therapy • Lung transplantation is not a cure for CF and ongoing CF team care should continue after lung transplantation • Referral to the transplant centre should be made in a timely fashion using international referral criteria as a guide • Pre-transplant assessment of physical, functional, microbiological and psychological parameters is used to determine candidate suitability • Pre-transplant optimization of physical functioning and nutrition is essential to increase the chance of a successful transplant outcome • Immunosuppressive drugs are required lifelong after lung transplant and are associated with significant side effects which can themselves cause morbidity • Early complications include primary graft dysfunction, infection and acute rejection of the transplanted lungs • Long-term survival is limited by development of chronic graft dysfunction causing marked remodelling of the airways known as Obliterative Bronchiolitis.

Chapter.  4438 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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