Chapter

Fertility, contraception and pregnancy

Frank Edenborough

in Cystic Fibrosis

Published on behalf of Oxford University Press

ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780199607563 | DOI: http://dx.doi.org/10.1093/med/9780199582709.003.0011

Series: Oxford Respiratory Medicine Library

Fertility, contraception and pregnancy

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Key points

Males

Most likely to be infertile – counsel early and do a sperm test at around 18yrs - Fatherhood is possible using sperm retrieval and in vitro fertilization (MESA and ICSI). -

Females

Menarche is likely to be delayed but regular menses is the norm unless in poor health - All women of reproductive age should be considered fertile and offered contraception - True fertility is unknown, but up to 2/3 women wishing to become pregnant do so naturally - The outcome for the mother is highly dependent on her pre-conceptual health, notably weight and lung function - For those unable to conceive, bypassing the cervical mucus plug (intrauterine insemination) or more formal in vitro fertilization techniques are available. -

Pregnancy

The outcome of pregnancy for the child is excellent - Maintaining the mothers health with full usual CF treatment far outweighs the risk to the baby from potential fetal drug toxicity - Risk of the child having CF depends on the partner's carrier status - The fetus can be tested by chorionic villus sampling or amniocentesis, or in IVF a healthy embryo can be selected by pre-implantation genetic diagnosis. -

Chapter.  3602 words. 

Subjects: Respiratory Medicine and Pulmonology

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