Future treatments

Uta Griesenbach, Jane Davies and Eric Alton

in Cystic Fibrosis

Published on behalf of Oxford University Press

ISBN: 9780199582709
Published online September 2011 | e-ISBN: 9780199607563 | DOI:

Series: Oxford Respiratory Medicine Library

Future treatments

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  • Respiratory Medicine and Pulmonology


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• Increased understanding of CF pathophysiology is leading to new therapies • Several gene therapy trials have established proof-of-principle for gene transfer in the airways, but a gene therapy-based treatment has not yet been developed • Small molecule drugs directed at class-specific CFTR mutations are showing promise in early phase trials • Drugs aimed at restoring hydration of the airway surface have been shown to improve mucociliary clearance • Increasing numbers of antibiotics are being formulated for both nebulization and inhalation.

Chapter.  2572 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology

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