Chapter

Pathophysiology and cellular mechanisms

Michael G. Hennerici, Rolf Kern, Kristina Szabo and Johannes Binder

in Stroke

Published on behalf of Oxford University Press

Published in print July 2012 | ISBN: 9780199582808
Published online July 2012 | e-ISBN: 9780191739651 | DOI: http://dx.doi.org/10.1093/med/9780199582808.003.003

Series: Oxford Neurology Library

Pathophysiology and cellular        mechanisms

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• Brain ischaemia initiates a cascade of events that evolve in time and space, and include harmful, as well as protective mechanisms. • Many factors influence stroke development and final outcome such as: (1) individual time course and topography of brain ischaemia; (2) mechanisms active during impaired perfusion and reperfusion (‘ischaemic core and penumbra’); (3) vascular collateralization and preserved integrity of neurovascular units and neuronal networks; and (4) neuronal repair strategies. • Sequential neuroimaging (CT, MRI, ultrasound) supports the clinical diagnosis and monitoring of stroke victims, helps to identify complications, establish interventional treatment options and better predict prognosis

Chapter.  2078 words.  Illustrated.

Subjects: Neurology

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