Specific treatment of acute ischaemic stroke

Michael G. Hennerici, Rolf Kern, Kristina Szabo and Johannes Binder

in Stroke

Published on behalf of Oxford University Press

Published in print July 2012 | ISBN: 9780199582808
Published online July 2012 | e-ISBN: 9780191739651 | DOI:

Series: Oxford Neurology Library

Specific treatment of acute        ischaemic stroke

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• Intravenous administration of alteplase within 3hr to onset has been the only approved specific medical therapy for the treatment of patients with acute ischaemic stroke. Recent data suggesting a benefit of therapy up to 4.5hr resulted in approval of this time window. However earlier treatment (<90min) is more likely to result in a favourable outcome. • In carefully selected patients interventional approaches might be an option for treatment in a stroke centre with experienced specialists. • In patients with BA occlusion, treatment should be initiated as soon as possible. In many stroke unit settings this means starting iv thrombolysis and considering additonal ia thrombolysis. • In patients <60yrs with malignant MCA stroke early hemicraniectomy reduces mortality and might improve long-term outcome.

Chapter.  3385 words.  Illustrated.

Subjects: Neurology

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