Chapter

Pharmacology of antipsychotic long-acting injections*

Tim Lambert and David Taylor

in Antipsychotic long-acting injections

Published on behalf of Oxford University Press

Published in print October 2010 | ISBN: 9780199586042
Published online February 2013 | e-ISBN: 9780191754708 | DOI: http://dx.doi.org/10.1093/med/9780199586042.003.0002
Pharmacology of antipsychotic long-acting injections*

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In this chapter we discuss the applied pharmacology of antipsychotic long-acting injections (LAIs). We begin with an overview of the basic pharmacology of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) LAIs, review the clinical applications of working with LAI kinetics, examine dosing equivalence between the LAIs and the common frequencies of administration, review initiation and loading strategies to achieve rapid plasma level changes, consider some of the pharmacodynamics of the various LAI formulations, and finally conclude with a brief overview of the pharmacology of switching to and from LAI antipsychotics. The objective of this chapter is to present sufficient material for the general clinician to understand the main differences between agents and to set the scene for an evidence-based approach to prescribing (see Chapter 10).

Chapter.  10694 words.  Illustrated.

Subjects: Psychiatry

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