Pain and autonomic nerve blocks

Mick Serpell and Andreas Goebel

in Principles and Practice of Regional Anaesthesia

Fourth edition

Published on behalf of Oxford University Press

Published in print November 2012 | ISBN: 9780199586691
Published online November 2012 | e-ISBN: 9780191755507 | DOI:

Series: Oxford Textbooks in Anaesthesia

Pain and autonomic nerve blocks

More Like This

Show all results sharing these subjects:

  • Anaesthetics
  • Clinical Skills


Show Summary Details


The sympathetic nervous system was, for a long time, the target for pain relieving techniques, but they are now used much less frequently than in the past because the mechanisms of pain are better understood. The role of the sympathetic nervous system in the generation and maintenance of pain may have been overemphasized previously (Schott 1998) so the rational for sympathetic block in chronic pain management is being re-evaluated. Systemic medication, stimulation techniques, physical therapy, and psychological techniques are all used much more widely than previously. When it is used, sympathetic block can be produced in one of three ways: 1. Direct injections of the sympathetic chain or related ganglia using local anaesthetic or neurolytic solutions; 2. Venous injection, with the circulation excluded by tourniquet, of drugs which deplete adrenergic transmitters—intravenous regional sympathetic block (IVRSB); and 3. Systemic administration (by intravenous infusion) of α-adrenergic antagonist drugs. The analgesic effect of most nerve block techniques (e.g. an epidural in labour or coeliac plexus for cancer pain) is a result of the interruption of transmission in afferent nociceptive fibres, but the effects of sympathetic nerve block can be more complex. The sympathetic nervous system is directly involved in the pathophysiology of some painful states (‘sympathetically maintained pain’), and the analgesic action is due primarily to block of sympathetic efferent activity. There may also be disruption of reflex control systems so that peripheral or central sensory processing is altered. Finally, peripheral vasodilatation can relieve pain due to ischaemia.

Chapter.  10936 words.  Illustrated.

Subjects: Anaesthetics ; Clinical Skills

Full text: subscription required

How to subscribe Recommend to my Librarian

Buy this work at Oxford University Press »

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.