The immunocompromised host: (b) patients with haematological disorders

Jeremy Brown and James Brown

in Acute Respiratory Infections

Published on behalf of Oxford University Press

Published in print July 2012 | ISBN: 9780199588084
Published online October 2012 | e-ISBN: 9780191739668 | DOI:

Series: Oxford Respiratory Medicine Library

The immunocompromised host: (b) patients with haematological disorders

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Key points

Patients with haematological malignancy or who have had haematopoietic stem cell transplantation (HSCT) are often severely immunosuppressed, both due to the disease and as a result of the treatment - Infectious complications affecting the respiratory tract are common and frequently severe in these patients - There is a large range of pathogens that cause respiratory infections in haematology patients, and opportunistic infection with cytomegalovirus, Aspergillus species, and Pneumocystis jirovecii are common - The likely microbial pathogen(s) can be narrowed down by assessment of the patient's underlying immune defect(s), the clinical presentation, the radiological features on the CT scan, and carefully targeted investigations - Early use of empirical broad-spectrum antibiotics is essential in these patients if they present with symptoms or signs of a respiratory infection - Expert advice is necessary unless there is a rapid response to empirical antibiotics.

Chapter.  3467 words.  Illustrated.

Subjects: Respiratory Medicine and Pulmonology ; Immunology

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