Chapter

Cellular metabolism

Robert Wilkins, Simon Cross, Ian Megson and David Meredith

in Oxford Handbook of Medical Sciences

Second edition

Published on behalf of Oxford University Press

ISBN: 9780199588442
Published online September 2011 | e-ISBN: 9780191729881 | DOI: http://dx.doi.org/10.1093/med/9780199588442.003.0002

Series: Oxford Medical Handbooks

Cellular metabolism

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Contents

General principles Overview - Metabolic control - Oxidation and reduction - Body energy supplies - - Central metabolic pathways Tricarboxylic acid cycle and its control - Mitochondrial oxidation—the electron transport chain - ATP synthesis—the chemiosmotic theory - ATP synthesis—uses of the proton motive force - ATP synthesis—control - - Fat as a fuel Overview - Assimilation of dietary fat - β-oxidation - Biosynthesis by the liver - Ketogenesis by the liver - Integration - - Glucose as a fuel Overview - Glycolysis - Control of glycolysis - Use of other monosaccharides - Aerobic oxidation of glucose - Pentose phosphate pathway - Storage of glucose—glycogen breakdown and synthesis - Regulation of glycogen synthesis and breakdown - Gluconeogenesis - - Amino acid metabolism Overview - Oxidation - Urea cycle - Tissue specific metabolism - - Cellular organization of metabolism Mitochondria - Endoplasmic reticulum and Golgi apparatus - Lysosomes - Peroxisomes - Protection of cells against reactive oxygen species - - Integration and regulation of metabolism Overview - Cellular metabolic response to feeding - Cellular metabolic response to fasting and starvation - Cellular metabolic response to exercise - Pregnancy and lactation - Diabetes mellitus - - Clinical aspects Energy balance - Nutrition - Assays: diagnostic enzymology - Inborn errors of metabolism - Obesity and treatment - -

Chapter.  18827 words.  Illustrated.

Subjects: Preclinical Medicine ; Physiology

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