Chapter

Unicellular Models

S. Codlin and R.L. Haines

in The Neuronal Ceroid Lipofuscinoses (Batten Disease)

Second edition

Published on behalf of Oxford University Press

Published in print March 2011 | ISBN: 9780199590018
Published online November 2012 | e-ISBN: 9780191753459 | DOI: http://dx.doi.org/10.1093/med/9780199590018.003.0015

Series: Contemporary Neurology Series

Unicellular Models

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Unicellular eukaryotes have many advantages as model organisms since they are easy to grow and maintain, have short cell cycles, and there are many tools and approaches available to assist analysis. Two such organisms, the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe, have been utilized in the study of NCLs, since several NCL genes and their gene products are conserved in these species. Both have orthologues for the proteins CLN3, designated Btn1p, and cathepsin D, designated Pep4p in S. cerevisiae or Sxa1p in S. pombe. The fission yeast, S. pombe, also has a CLN1 orthologue, designated Ppt1p.

Chapter.  6327 words. 

Subjects: Neurology

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