Chapter

Lessons from the study of natural experiments of hyperendemic foci of neurodegeneration

Ralph M. Garruto

in Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

Published on behalf of Oxford University Press

Published in print October 2012 | ISBN: 9780199590674
Published online November 2012 | e-ISBN: 9780191753466 | DOI: http://dx.doi.org/10.1093/med/9780199590674.003.0001
Lessons from the study of natural experiments of hyperendemic foci of neurodegeneration

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Gajdusek’s contributions to the understanding of neurodegenerative diseases through studies of focal disease in isolated human groups is legendary and a landmark in the history of science. We who follow, and who have spent decades in search of answers like our mentor’s,are simply running out of time, not only with respect to the disappearance of disease in these foci, but as a result of the limitations of our own mortality. Still, scholars from around the world continue to have a profound interest in these foci, and they pursue ongoing questions of aetiology and mechanisms of pathogenesis, an understanding of which will have consequences for our understanding of neurodegenerative diseases globally.

Chapter.  11065 words.  Illustrated.

Subjects: Neurology

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