Chapter

Electrophysiological evaluation of lower motor neurone loss in amyotrophic lateral sclerosis

Jeremy M. Shefner

in Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

Published on behalf of Oxford University Press

Published in print October 2012 | ISBN: 9780199590674
Published online November 2012 | e-ISBN: 9780191753466 | DOI: http://dx.doi.org/10.1093/med/9780199590674.003.0012
Electrophysiological evaluation of lower motor neurone loss in amyotrophic lateral sclerosis

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Although still being refined, MUNE has provided important information about disease course in patients with ALS, and has served as a sensitive marker of motor neurone loss in animal models. Modifications in current techniques have the potential to reduce variability of measurement and improve ease of use. As a surrogate outcome measure in phase II clinical trials, MUNE may reduce sample size required to show a meaningful effect of therapy as compared with other commonly used measures.

Chapter.  5674 words.  Illustrated.

Subjects: Neurology

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