Chapter

Multimodality approach to neuroimaging in amyotrophic lateral sclerosis/frontotemporal dementia

Jan Kassubek and Albert C. Ludolph

in Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

Published on behalf of Oxford University Press

Published in print October 2012 | ISBN: 9780199590674
Published online November 2012 | e-ISBN: 9780191753466 | DOI: http://dx.doi.org/10.1093/med/9780199590674.003.0013
Multimodality approach to neuroimaging in amyotrophic lateral sclerosis/frontotemporal dementia

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In summary, each of the methodologies applied to imaging the brain in ALS have provided discrete bundles of information that have enhanced our understanding of the non-motor manifestations of the disease process. In general, they have provided clear evidence of pathological involvement of the frontal and temporal lobes, particularly the anterior cingulate and anterior temporal lobes, while also delineating a more widespread impairment of rCBF, discrete regions of neuronal loss (or loss of neuronal receptors) and activation of glia. The promise of MR spectroscopy (not discussed here, but see 33) and DTI to further define the neuroanatomical substrate of the frontotemporal syndromes of ALS is as yet not fully tapped. Combining these techniques with rigorous neuropsychological evaluations will be critical. Indeed, we have come a long way from reviewers believing that we were simply wrong—the neuropsychological manifestations of ALS are indeed significant and can be clearly linked to neuroimaging correlates.

Chapter.  4734 words.  Illustrated.

Subjects: Neurology

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