Chapter

The neuropathology of the motor neurone diseases

J. Robin Highley and Paul G. Ince

in Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

Published on behalf of Oxford University Press

Published in print October 2012 | ISBN: 9780199590674
Published online November 2012 | e-ISBN: 9780191753466 | DOI: http://dx.doi.org/10.1093/med/9780199590674.003.0019
The neuropathology of the motor neurone diseases

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This chapter describes the neuropathology of a core group of motor neurone diseases (MNDs), including amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), and primary lateral sclerosis (PLS). Other motor neurone disorders are not discussed, and the reader is directed elsewhere.

Pathological and clinical investigation of MND have proceeded hand in hand ever since its first description by Charcot. The last two decades have seen an exponential growth in our neuropathological understanding of MND, shifting the emphasis from an exclusively motor system disease to a disease that affects multiple brain systems as part of a spectrum of disorders. The existence of this book attests to considerable pathological overlap between MND and frontotemporal lobar degeneration (FTLD), covered in Chapter 18 by Cairns.

Chapter.  6050 words.  Illustrated.

Subjects: Neurology ; Pathology

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