Chapter

Transactive response DNA-binding protein of 43 kDa

Emanuele Buratti

in Amyotrophic Lateral Sclerosis and the Frontotemporal Dementias

Published on behalf of Oxford University Press

Published in print October 2012 | ISBN: 9780199590674
Published online November 2012 | e-ISBN: 9780191753466 | DOI: http://dx.doi.org/10.1093/med/9780199590674.003.0024
Transactive response DNA-binding protein of 43 kDa

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Transactive response DNA-binding protein of 43 kDa (TDP-43) is an ubiquitously expressed RNA-binding protein (RBP) belonging to the heterogeneous ribonucleoprotein (hnRNP) family and containing two RNA-recognition motif domains for target RNA binding and a glycine-rich C-terminal tail required for protein–protein interaction (the sequence of this protein and its functional regions are schematically depicted in Figure 24.1(A,B). In normal conditions, TDP-43 is predominantly localized in the nucleus, but recent research has confirmed that this protein can also shuttle between this compartment and the cytoplasm, a property that may be important during axonal regeneration processes.

Chapter.  4697 words.  Illustrated.

Subjects: Neurology

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