Immunoglobulin A-dominant post-infectious glomerulonephritis

Bernardo Rodriguez-Iturbe and Mark Haas

in Oxford Textbook of Clinical Nephrology

Published on behalf of Oxford University Press

Published in print October 2015 | ISBN: 9780199592548
Published online October 2015 | e-ISBN: 9780191779145 | DOI:
Immunoglobulin A-dominant post-infectious glomerulonephritis

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Immunoglobulin A (IgA)-dominant post-infectious glomerulonephritis is usually associated with infections with Staphylococcus aureus. It is most commonly seen in patients over 60, and particularly in men. The renal lesion is acute and severe, and commonly includes crescent formation, although the described histological features vary widely. IgA is the dominant immunoglobulin and in later phases when capillary deposits are resolving it may be impossible to distinguish the condition from IgA nephropathy without the use of electron microscopy. Diabetes appears to be a risk factor. Complement levels are frequently low but may be normal. Clinically there is often severe nephrotic syndrome and hypertension may be less prominent.

Chapter.  1667 words.  Illustrated.

Subjects: Nephrology ; Surgery

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