Chapter

Pathophysiology of type 2 diabetes

Sarah Steven and Roy Taylor

in Type 2 Diabetes

Second edition

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199596171
Published online January 2012 | e-ISBN: 9780191739699 | DOI: http://dx.doi.org/10.1093/med/9780199596171.003.0028

Series: Oxford Diabetes Library

Pathophysiology of type 2 diabetes

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• There are defects in both insulin sensitivity and insulin secretion • Environmental factors determine prevalence in populations and risk in individuals • Longstanding positive energy balance is a sine qua non of type 2 diabetes • Liver fat levels are elevated before onset of type 2 diabetes • Genetic factors determine degree of susceptibility to environmental influences • Even extreme degrees of insulin resistance do not cause hyperglycaemia if beta cell function is good • Decrease in beta cell function characterizes the transition from impaired glucose tolerance to diabetes • Excess deposition and availability of fat within organs, particularly the liver, is central in the pathophysiology of type 2 diabetes.

Chapter.  6301 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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