Chapter

Interpretation of recent clinical trials concerning tight glycaemic control and cardiovascular risk

Cristina Bianchi and Stefano Del Prato

in Type 2 Diabetes

Second edition

Published on behalf of Oxford University Press

Published in print May 2010 | ISBN: 9780199596171
Published online January 2012 | e-ISBN: 9780191739699 | DOI: http://dx.doi.org/10.1093/med/9780199596171.003.0038

Series: Oxford Diabetes Library

Interpretation of recent clinical trials concerning tight glycaemic control and cardiovascular risk

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• Recent intervention trials have shown some impact on microvascular complications but limited or no effect on vascular risk • Microvascular benefit of tight glycaemic control should be weighed against the increase in total and CV-related mortality, increased weight gain, and risk for severe hypoglycaemia • Hypoglycaemia rather than a trigger factor for CV events may be a marker for vulnerable patients • Avoiding risks of tight glycaemic control requires • Early and effective intervention • Personalized glycaemic targets • Careful selection of pharmacologic intervention.

Chapter.  4332 words.  Illustrated.

Subjects: Endocrinology and Diabetes

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