Chapter

The causes and mechanisms of multiple sclerosis

Neil Scolding and Alastair Wilkins

in Multiple Sclerosis

Published on behalf of Oxford University Press

Published in print July 2012 | ISBN: 9780199603251
Published online January 2012 | e-ISBN: 9780191739705 | DOI: http://dx.doi.org/10.1093/med/9780199603251.003.0010

Series: Oxford Neurology Library

The causes and mechanisms of multiple sclerosis

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• Epidemiological studies of MS have been highly informative in guiding the search for aetiological factors in MS • There are genetic influences governing disease susceptibility, the strongest of those being immune system genes • No proven environmental ‘cause’ for MS has been discovered although several factors are thought to be important • MS is immunologically driven and is likely to be initiated by autoimmune dysregulation • A number of pathological processes occur in the central nervous system which are responsible for tissue damage and clinical manifestations of the disease.

Chapter.  6168 words.  Illustrated.

Subjects: Neurology

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