Clinical presentations and disease course of multiple sclerosis

Neil Scolding and Alastair Wilkins

in Multiple Sclerosis

Published on behalf of Oxford University Press

Published in print July 2012 | ISBN: 9780199603251
Published online January 2012 | e-ISBN: 9780191739705 | DOI:

Series: Oxford Neurology Library

Clinical presentations and disease course of multiple sclerosis

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• MS commonly presents with sub-acutely deteriorating focal neurological symptoms and signs—the classical relapsing-remitting course • Around 10% of patients present with slowly progressive neurological problems—primary progressive MS • progressive and relapsing components of MS are clinically and pathologically quite different • Devic's disease, or neuromyelitis, is associated with anti-aquaporin 4 antibodies and a distinct clinical and radiological phenotype • Acute disseminated encephalomyelitis (ADEM) can sometimes resemble MS, but carries a more serious immediate risk, though it does not pursue a chronic progressive course in survivors of the acute illness.

Chapter.  2492 words. 

Subjects: Clinical Medicine

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