Chapter

A serendipitous discovery

Madeleine Ennis

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0011

Series: Landmark Papers

A serendipitous discovery

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It has been made clear . . . that the peculiarly and rapidly fatal character of anaphylactic shock in the guinea-pig depends on the valve-like closure of the bronchioles . . . My own experiments began some time ago with the accidental observation of the extraordinary sensitiveness to horse serum of certain isolated uteri, which I was using for another purpose. Enquiry revealed the fact that the guinea-pigs from which they were taken were all survivors from antitoxin standardisations. Testing the uterus from a normal guinea-pig I found no response of the kind.

Chapter.  1250 words.  Illustrated.

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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