Chapter

Does eczema have an allergic aetiology?

Michael Ardern-Jones

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0013

Series: Landmark Papers

Does eczema have an allergic aetiology?

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The so-called idiosyncrasies which occur in many people who suffer from urticaria, vomiting and angioneurotic edema after the ingestion of certain foods seem to depend upon an acquired or possibly an inherited hypersensitiveness to the particular protein involved . . . it seems reasonable to assume that a person is sensitive to protein or that he has an idiosyncrasy to the protein of a food if an urticarial wheal develops after a protein substance or a food has been rubbed upon an abraded surface, which constitutes cutaneous test. This method was used by Smith, Schloss and Talbot. I have used this method, as well as the injection of the substance into the skin, which I designate the intracutaneous test. In the tests here reported the skin was scarified with a needle and the substances used were gently rubbed in. The scarification should be superficial and blood should not be drawn. A positive reaction is shown by the appearance of an urticarial wheal or of marked erythema and edema at the point of scarification. The reaction appears within the first five minutes, increases rapidly and reaches its height in ten or fifteen minutes. It gradually subsides, but in the majority of instances the papule persists thirty minutes or more.

Chapter.  1160 words.  Illustrated.

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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