Chapter

Identification of slow-reacting substance

Sven-Erik Dahlén

in Landmark Papers in Allergy

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199651559
Published online April 2013 | e-ISBN: 9780191754241 | DOI: http://dx.doi.org/10.1093/med/9780199651559.003.0021

Series: Landmark Papers

Identification of slow-reacting substance

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In recent experiments carried out in this laboratory evidence has been brought forward . . . that the contraction of smooth muscle caused by different venoms are [caused] by a ‘slow-reacting smooth muscle-stimulating substance [SRS]’ which may largely determine the nature of the responses. Bartosch, Feldberg and Nagal (1932) have shown that the injection of the anaphylactic antigen into the perfused lung of the sensitized guinea-pig caused the liberation of histamine. Our experiments show in addition that a substance which in its action on the isolated jejunum of the guinea pig resembles that formed by the action of snake venoms on egg yolk or perfused tissues appears in the outflowing perfusate from the lung after the anaphylactic response. This substance may be identical with that formed by the action of snake venom, though we have no proof that this is the case. For convenience, however, we shall refer to it as SRS.

Chapter.  1530 words.  Illustrated.

Subjects: Public Health and Epidemiology ; Immunology ; Respiratory Medicine and Pulmonology

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